For the complement system to cause AMD, there must be initiation (a ‘trigger’), amplification, and local retinal damage caused by the process. The alternative pathway of the complement system is ...

Complement molecules are the immune proteins responsible for identifying bacteria, viruses, and other foreign invaders as they circulate through our bodies. Their function helps lymphocytes to locate ...

The mammalian immune system is a remarkable complex of biochemical processes enabling efficient detection and prosecution of pathogens that threaten host viability. The incredible complexity of ...

Atypical hemolytic uremic syndrome (aHUS) is a rare and severe form of thrombotic microangiopathy caused by genetic or acquired abnormalities of the alternative pathway (AP) of complement activation, ...

Nipocalimab might lower the concentration of anti-acetylcholine receptor antibodies in people with generalized myasthenia gravis, a study shows. PHOENIX, Arizona—Nipocalimab might lower the ...

Hemolytic uremic syndrome caused by an invasive Streptococcus pneumoniae infection (SP-HUS) is a rare and severe disease that primarily affects children under two years of age. The pathophysiology of ...

The complement system is one of the crucial pathophysiological mechanisms that directly influence the function of a transplanted kidney. Since the complement pathways’ activation potential can be ...